Fascicles and the interfascicular matrix show decreased fatigue life with ageing in energy storing tendons

Thorpe, Chavaunne T, Riley, Graham P, Birch, Helen L, Clegg, Peter D and Screen, Hazel R C (2017) Fascicles and the interfascicular matrix show decreased fatigue life with ageing in energy storing tendons. Acta Biomaterialia, 56. 58–64. ISSN 1742-7061

[img]
Preview
PDF (Published manuscript) - Published Version
Available under License Creative Commons Attribution.

Download (1MB) | Preview

Abstract

Tendon is composed of rope-like fascicles bound together by interfascicular matrix (IFM). The IFM is critical for the function of energy storing tendons, facilitating sliding between fascicles to allow these tendons to cyclically stretch and recoil. This capacity is required to a lesser degree in positional tendons. We have previously demonstrated that both fascicles and IFM in energy storing tendons have superior fatigue resistance compared with positional tendons, but the effect of ageing on the fatigue properties of these different tendon subunits has not been determined. Energy storing tendons become more injury-prone with ageing, indicating reduced fatigue resistance, hence we tested the hypothesis that the decline in fatigue life with ageing in energy storing tendons would be more pronounced in the IFM than in fascicles. We further hypothesised that tendon subunit fatigue resistance would not alter with ageing in positional tendons. Fascicles and IFM from young and old energy storing and positional tendons were subjected to cyclic fatigue testing until failure, and mechanical properties were calculated. The results show that both IFM and fascicles from the SDFT exhibit a similar magnitude of reduced fatigue life with ageing. By contrast, the fatigue life of positional tendon subunits was unaffected by ageing. The age-related decline in fatigue life of tendon subunits in energy storing tendons is likely to contribute to the increased risk of injury in aged tendons. Full understanding of the mechanisms resulting in this reduced fatigue life will aid in the development of treatments and interventions to prevent age-related tendinopathy.

Item Type: Article
Uncontrolled Keywords: tendon,fascicle,interfascicular matrix,mechanical testing,fatigue resistance ,creep
Faculty \ School: Faculty of Science > School of Biological Sciences
Depositing User: Pure Connector
Date Deposited: 16 Mar 2017 01:35
Last Modified: 17 Mar 2020 23:09
URI: https://ueaeprints.uea.ac.uk/id/eprint/62982
DOI: 10.1016/j.actbio.2017.03.024

Actions (login required)

View Item View Item