Expedient synthesis of an atypical oxazolidinone compound library

Cully, Sarah J., Storr, Thomas E., Rawling, Michael J., Abeysena, Induka R., Hamza, Daniel, Jones, Geraint, Pearce, Christopher A., Quddus, Abdul, Lewis, William and Stockman, Robert A. (2016) Expedient synthesis of an atypical oxazolidinone compound library. Bioorganic & Medicinal Chemistry, 24 (21). pp. 5249-5257. ISSN 0968-0896

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Abstract

In order to address the current downturn in the drug discovery pipeline, initiatives are being undertaken to synthesise screening libraries of sp3-rich, low molecular weight compounds. As part of the European Lead Factory initiative, the synthesis and derivatisation of a simple hexahydrooxazolo[5,4-c]pyridin-2(1H)-one bicyclic carbamate has been achieved. The synthetic route employed involved a telescoped hetero-Diels–Alder/[2,3]-sigmatropic rearrangement/cyclisation sequence to deliver the desired core scaffold containing two points for further diversification. When applied, this synthesis was found to be robust and scalable which allowed the production of a 155 compound library.

Item Type: Article
Uncontrolled Keywords: sp3-rich,library,bicyclic,scaffold,oxazolidinone
Faculty \ School: Faculty of Science > School of Chemistry
Related URLs:
Depositing User: Pure Connector
Date Deposited: 14 Mar 2017 01:41
Last Modified: 22 Jul 2020 01:19
URI: https://ueaeprints.uea.ac.uk/id/eprint/62945
DOI: 10.1016/j.bmc.2016.08.046

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