Thomas, Kim S, Ormerod, Anthony D, Craig, Fiona E, Greenlaw, Nicola, Norrie, John, Mitchell, Eleanor, Mason, James M, Johnston, Graham A, Wahie, Shyamal and Williams, Hywel C and UK Dermatology Clinical Trials Network's STOP GAP Team (2016) Clinical outcomes and response of patients applying topical therapy for pyoderma gangrenosum: A prospective cohort study. Journal of the American Academy of Dermatology, 75 (5). pp. 940-949. ISSN 0190-9622
Full text not available from this repository.Abstract
BACKGROUND: Pyoderma gangrenosum (PG) is an uncommon dermatosis with a limited evidence base for treatment. OBJECTIVE: We sought to estimate the effectiveness of topical therapies in the treatment of patients with PG. METHODS: This was a prospective cohort study of UK secondary care patients with a clinical diagnosis of PG that was suitable for topical treatment (recruited between July 2009 and June 2012). Participants received topical therapy after normal clinical practice (primarily topical corticosteroids [classes I-III] and tacrolimus 0.03% or 0.1%). The primary outcome was speed of healing at 6 weeks. Secondary outcomes included the following: proportion healed by 6 months; time to healing; global assessment; inflammation; pain; quality of life; treatment failure; and recurrence. RESULTS: Sixty-six patients (22-85 years of age) were enrolled. Clobetasol propionate 0.05% was the most commonly prescribed therapy. Overall, 28 of 66 (43.8%) ulcers healed by 6 months. The median time to healing was 145 days (95% confidence interval, 96 days to ∞). Initial ulcer size was a significant predictor of time to healing (hazard ratio, 0.94 [95% confidence interval, 0.88-1.00); P = .043). Four patients (15%) had a recurrence. LIMITATIONS: Our study did not include a randomized comparator. CONCLUSION: Topical therapy is potentially an effective first-line treatment for PG that avoids the possible side effects associated with systemic therapy. It remains unclear whether more severe disease will respond adequately to topical therapy alone.
Item Type: | Article |
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Additional Information: | Crown Copyright © 2016. Published by Elsevier Inc. All rights reserved. |
Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
Related URLs: | |
Depositing User: | Pure Connector |
Date Deposited: | 15 Feb 2017 02:22 |
Last Modified: | 03 Nov 2022 15:42 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/62600 |
DOI: | 10.1016/j.jaad.2016.06.016 |
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