Acrodermatitis chronica atrophicans: a case report and review of the literature

Leslie, T A, Levell, N J, Cutler, S J, Cann, K J, Smith, M H F, Wright, D J M, Gilkes, J J H and Robinson, T W E (1994) Acrodermatitis chronica atrophicans: a case report and review of the literature. British Journal of Dermatology, 131 (5). pp. 687-693. ISSN 0007-0963

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Abstract

We report a 55-year-old woman with acrodermatitis chronica atrophicans (ACA) and a peripheral sensory neuropathy. ACA is an uncommon late cutaneous manifestation of Lyme disease, which follows disseminated Borrelia burgdorferi infection. This is the second published case from the U.K. since serological diagnosis has been available. In this patient the diagnosis was confirmed by serology using a sensitive enzyme-linked immunosorbent assay and immunoblotting techniques. B. burgdorferi DNA was demonstrated in the affected skin using the polymerase chain reaction, although staining and cultures for the organism were negative. Recommended treatment of ACA is with oral doxycycline 100 mg twice daily for 28 days, but our patient did not respond well to this regimen. She was therefore treated with ceftriaxone intravenously for 21 days, which resulted in a rapid symptomatic and clinical response.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 14 Feb 2017 02:23
Last Modified: 24 Apr 2020 23:51
URI: https://ueaeprints.uea.ac.uk/id/eprint/62510
DOI: 10.1111/j.1365-2133.1994.tb04984.x

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