An Assessment of the Next Generation of Animal miRNA Target Prediction Algorithms

Bradley, Thomas and Moxon, Simon ORCID: (2017) An Assessment of the Next Generation of Animal miRNA Target Prediction Algorithms. In: MicroRNA Detection and Target Identification. Methods in Molecular Biology . Springer, pp. 175-191. ISBN 978-1-4939-6864-0

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The advent of genome-wide next-generation sequencing technologies has revolutionized the genomic and transcriptomic fields. New technologies also present an opportunity for greater discovery and understanding of post-transcriptional processes, in particular, translational inhibition of transcripts by miRBP (microRNA-RNA binding protein) complexes. Not only have novel methodologies been developed for the direct sequencing of RBP-bound RNA, but a new class of miRNA (microRNA) target prediction algorithms trained on this data has emerged. In this article, we will explore and evaluate the next generation of animal miRNA target prediction algorithms, their relationship to more traditional prediction methods, and the implications of such methodologies for the future of miRNA target prediction and miRNA research as a whole.

Item Type: Book Section
Uncontrolled Keywords: mirna,mirna target prediction
Faculty \ School: Faculty of Science > School of Biological Sciences
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Depositing User: Pure Connector
Date Deposited: 11 Jan 2017 00:07
Last Modified: 10 Aug 2022 01:33
DOI: 10.1007/978-1-4939-6866-4_13

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