A plant immune receptor detects pathogen effectors that target WRKY transcription factors

Sarris, Panagiotis F., Duxbury, Zane, Huh, Sung Un, Ma, Yan, Segonzac, Cécile, Sklenar, Jan, Derbyshire, Paul, Cevik, Volkan, Rallapalli, Ghanasyam, Saucet, Simon B., Wirthmueller, Lennart, Menke, Frank L. H. ORCID: https://orcid.org/0000-0003-2490-4824, Sohn, Kee Hoon and Jones, Jonathan D. G. (2015) A plant immune receptor detects pathogen effectors that target WRKY transcription factors. Cell, 161 (5). pp. 1089-1100. ISSN 0092-8674

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Defense against pathogens in multicellular eukaryotes depends on intracellular immune receptors, yet surveillance by these receptors is poorly understood. Several plant nucleotide-binding, leucine-rich repeat (NB-LRR) immune receptors carry fusions with other protein domains. The Arabidopsis RRS1-R NB-LRR protein carries a C-terminal WRKY DNA binding domain and forms a receptor complex with RPS4, another NB-LRR protein. This complex detects the bacterial effectors AvrRps4 or PopP2 and then activates defense. Both bacterial proteins interact with the RRS1 WRKY domain, and PopP2 acetylates lysines to block DNA binding. PopP2 and AvrRps4 interact with other WRKY domain-containing proteins, suggesting these effectors interfere with WRKY transcription factor-dependent defense, and RPS4/RRS1 has integrated a "decoy" domain that enables detection of effectors that target WRKY proteins. We propose that NB-LRR receptor pairs, one member of which carries an additional protein domain, enable perception of pathogen effectors whose function is to target that domain.

Item Type: Article
Additional Information: Copyright © 2015 Elsevier Inc. All rights reserved.
Uncontrolled Keywords: amino acid sequence,arabidopsis,arabidopsis proteins,bacterial proteins,innate immunity,molecular sequence data,plant proteins,tertiary protein structure,pseudomonas fluorescens,pseudomonas syringae,tobacco
Faculty \ School: Faculty of Science > The Sainsbury Laboratory
Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Science > School of Biological Sciences
UEA Research Groups: Faculty of Science > Research Groups > Plant Sciences
Depositing User: Pure Connector
Date Deposited: 15 Dec 2016 00:05
Last Modified: 01 Jun 2023 12:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/61727
DOI: 10.1016/j.cell.2015.04.024

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