Novel nut and bolt task quantifies motor deficits in premanifest and manifest Huntington's Disease

Collins, Lucy M, Begeti, Faye, Panin, Francesca, Lazar, Alpar S, Cruickshank, Travis, Ziman, Mel, Mason, Sarah L and Barker, Roger A (2015) Novel nut and bolt task quantifies motor deficits in premanifest and manifest Huntington's Disease. PLoS Currents Disasters, 7. ISSN 2157-3999

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Abstract

BACKGROUND: We investigated the use of a simple novel nut and bolt task in premanifest and manifest Huntington's disease (HD) patients to detect and quantify motor impairments at all stages of the disease. METHODS: Premanifest HD (n=24), manifest HD (n=27) and control (n=32) participants were asked to screw a nut onto a bolt in one direction, using three different sized bolts with their left and right hand in turn. RESULTS: We identified some impairments at all stages of HD and in the premanifest individuals, deficits in the non-dominant hand correlated with disease burden scores. CONCLUSION: This simple, cheap motor task was able to detect motor impairments in both premanifest and manifest HD and as such might be a useful quantifiable measure of motor function for use in clinical studies.

Item Type: Article
Additional Information: Published under a Creative Commons Attribution License, enabling unrestricted distribution and use of the published materials, provided that its authors are properly credited.
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
Depositing User: Pure Connector
Date Deposited: 07 Dec 2016 00:07
Last Modified: 17 Mar 2020 22:44
URI: https://ueaeprints.uea.ac.uk/id/eprint/61605
DOI: 10.1371/currents.hd.ded251617ae62a1364506b0521bd3761

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