Nesprins LINC the nucleus and cytoskeleton

Mellad, Jason A., Warren, Derek T. and Shanahan, Catherine M. (2011) Nesprins LINC the nucleus and cytoskeleton. Current Opinion in Cell Biology, 23 (1). pp. 47-54. ISSN 0955-0674

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Like other spectrin repeat proteins, nesprins co-ordinate and maintain cellular architecture by linking membranous organelles to the cytoskeleton. However nuclear envelope (NE) nesprins, uniquely hardwire the nuclear lamina to the cytoskeleton and molecular motors. Emerging evidence suggests that nesprins also form a continuous network linking the plasma membrane to the NE that potentially translates mechanical stimuli into nuclear reorganisation. Surprisingly, this network is also essential for cytoskeletal organisation and its disruption has dramatic effects on nuclear migration, centrosomal positioning, focal adhesion maturation and cell motility. Herein we review recent advances in our understanding of how nesprins couple to various filamentous systems within the cell and emphasise the importance of both KASH and KASH-less nesprin isoforms in these interactions.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
UEA Research Groups: Faculty of Science > Research Groups > Molecular and Tissue Pharmacology
Related URLs:
Depositing User: Pure Connector
Date Deposited: 23 Nov 2016 00:42
Last Modified: 22 Oct 2022 01:55
DOI: 10.1016/

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