Many routes to the same destination:lessons from skeletal muscle development

Mok, Gi Fay ORCID: and Sweetman, Dylan (2011) Many routes to the same destination:lessons from skeletal muscle development. Reproduction, 141. pp. 301-312. ISSN 1470-1626

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The development and differentiation of vertebrate skeletal muscle provide an important paradigm to understand the inductive signals and molecular events controlling differentiation of specific cell types. Recent findings show that a core transcriptional network, initiated by the myogenic regulatory factors (MRFs; MYF5, MYOD, myogenin and MRF4), is activated by separate populations of cells in embryos in response to various signalling pathways. This review will highlight how cells from multiple distinct starting points can converge on a common set of regulators to generate skeletal muscle.

Item Type: Article
Uncontrolled Keywords: animals,extremities,gene regulatory networks,head,humans,models, biological,muscle development,muscle, skeletal,neck,signal transduction,vertebrates
Faculty \ School: Faculty of Science > School of Biological Sciences
Depositing User: Pure Connector
Date Deposited: 15 Nov 2016 13:00
Last Modified: 22 Oct 2022 01:53
DOI: 10.1530/REP-10-0394

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