SERRATE: a new player on the plant microRNA scene

Lobbes, Dajana, Rallapalli, Ghanasyam, Schmidt, Dominik D, Martin, Cathie and Clarke, Jonathan (2006) SERRATE: a new player on the plant microRNA scene. EMBO Reports, 7 (10). pp. 1052-1058. ISSN 1469-221X

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MicroRNAs (miRNAs) function as sequence-specific guides that control gene expression by post-transcriptional gene silencing. Many miRNAs influence plant development by regulating the accumulation of transcripts that encode transcription factors. Mutants defective in miRNA accumulation, such as dcl1, hen1, hyl1 and ago1, have pleiotropic developmental phenotypes. The serrate-1 (se-1) mutant of Arabidopsis also shows a highly pleiotropic phenotype, which overlaps with the phenotypes of mutants defective in miRNA accumulation. Although it has been proposed that SERRATE (SE) functions specifically in miRNA-mediated repression of the leaf polarity genes PHABULOSA and PHAVOLUTA, microarray analysis shows upregulation of many genes known to be the targets of miRNAs in se-1. We show that SE is a general regulator of miRNA levels affecting the processing of primary miRNA to miRNA.

Item Type: Article
Uncontrolled Keywords: alleles,arabidopsis,arabidopsis proteins,calcium-binding proteins,gene expression regulation, plant,genes, plant,intercellular signaling peptides and proteins,membrane proteins,micrornas,phenotype,plants, genetically modified,protein binding,rna stability,rna, plant,rna-binding proteins,seeds
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Science > School of Biological Sciences
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Depositing User: Pure Connector
Date Deposited: 09 Nov 2016 13:00
Last Modified: 12 Jun 2023 12:41
DOI: 10.1038/sj.embor.7400806

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