The association of vascular risk factors with visual loss in giant cell arteritis

Yates, Max, MacGregor, Alex J. ORCID:, Robson, Joanna, Craven, Anthea, Merkel, Peter A., Luqmani, Raashid A. and Watts, Richard A. (2017) The association of vascular risk factors with visual loss in giant cell arteritis. Rheumatology, 56 (4). pp. 524-528. ISSN 1462-0324

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Objective: Blindness is a recognised complication of giant cell arteritis (GCA); however the frequency and risk factors for this complication have not been firmly established. This study examined the incidence and determinants of blindness in patients with GCA using a large international cohort. Methods: The analysis was conducted among subjects recruited into the Diagnosis and Classification Criteria in Vasculitis Study (DCAVS). The study captures consecutive patients presenting to clinic-based physicians. New onset blindness was assessed six months after diagnosis by completion of the Vasculitis Damage Index (VDI). Logistic regression analysis was used to assess the association between blindness and clinical variables. Results: Of 433 patients with GCA from 26 countries, 7.9% presented with blindness in at least one eye at six months. Risk factors identified at baseline for blindness at six months were identified and included prevalent stroke (OR = 4.47, 95% CI: 1.30 to 15.41), and peripheral vascular disease (OR = 10.44, 95% CI: 2.94 to 37.03). Conclusion: This is the largest study to date of subjects with incident GCA and confirms that blindness remains a common complication of disease and is associated with established vascular disease.

Item Type: Article
Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in Rheumatology following peer review. The version of record is available online at: (DOI: 10.1093/rheumatology/kew397)
Uncontrolled Keywords: giant cell,arteritis,blindness,dcvas,vdi
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Pure Connector
Date Deposited: 03 Nov 2016 14:00
Last Modified: 20 Apr 2023 00:18
DOI: 10.1093/rheumatology/kew397

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