Association between lower limb osteoarthritis and incidence of depressive symptoms: data from the Osteoarthritis Initiative

Veronese, Nicola, Stubbs, Brendon, Solmi, Marco, Smith, Toby O, Noale, Marianna, Cooper, Cyrus and Maggi, Stefania (2017) Association between lower limb osteoarthritis and incidence of depressive symptoms: data from the Osteoarthritis Initiative. Age and Ageing, 46 (3). pp. 470-476. ISSN 0002-0729

[img]
Preview
PDF (Accepted manuscript) - Submitted Version
Download (252kB) | Preview

Abstract

Background: Osteoarthritis (OA) is associated with a number of medical morbidities. Although the prevalence of depression and depressive symptoms is presumed to be high in people with OA, no prospective comparative study has analyzed its incidence.  Objective: To determine whether OA was associated with an increased odds of developing depressive symptoms.  Design: Longitudinal cohort study (follow-up: four years).  Setting: Data were gathered from the North American Osteoarthritis Initiative (OAI) dataset.  Subjects: People at higher risk developing OA.  Methods: Osteoarthritis diagnosis was defined as the presence of OA at hand, knee, hip, back/neck or other sites at baseline. Depressive symptoms were defined using the 20-item Center for Epidemiologic Studies-Depression (cut-off 16 points) after four years.  Results: 3,491 people without depressive symptoms at baseline were analyzed (1,506 with OA/1,985 without). Using an adjusted logistic regression analysis for 12 potential confounders, people with OA had a similar odds of depressive symptoms at follow-up compared to those without OA (Odds Ratio (OR): 1.26; 95% CI: 0.95-1.67). However, multisite OA (i.e. OA 2>sites; OR: 1.48, 95% CI 1.07-2.05) and the specific presence of hip (OR: 1.72; 95% CI: 1.08-2.73) or knee OA (OR: 1.43; 95% CI: 1.03-1.98) were associated with a greater odds of developing depressive symptoms compared to people without OA.  Conclusions: This is the first study of longitudinal data to demonstrate people with multi-site, hip or knee OA have a greater odds of developing depressive symptoms compared to people without OA. This suggests that OA may be associated with future mental health burden.

Item Type: Article
Uncontrolled Keywords: osteoarthritis,depression,depressive symptoms,epidemiology
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
Related URLs:
Depositing User: Pure Connector
Date Deposited: 26 Oct 2016 12:00
Last Modified: 22 Jul 2020 01:09
URI: https://ueaeprints.uea.ac.uk/id/eprint/61069
DOI: 10.1093/ageing/afw216

Actions (login required)

View Item View Item