No compensatory relationship between the innate and adaptive immune system in wild-living European badgers

Sin, Yung Wa, Newman, Chris, Dugdale, Hannah L., Buesching, Christina, Mannarelli, Maria-Elena, Annavi, Geetha, Burke, Terry and Macdonald, David W. (2016) No compensatory relationship between the innate and adaptive immune system in wild-living European badgers. PLoS One, 11 (10). ISSN 1932-6203

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Abstract

The innate immune system provides the primary vertebrate defence system against pathogen invasion, but it is energetically costly and can have immune pathological effects. A previous study in sticklebacks found that intermediate major histocompatibility complex (MHC) diversity correlated with a lower leukocyte coping capacity (LCC), compared to individuals with fewer, or many, MHC alleles. The organization of the MHC genes in mammals, however, differs to the highly duplicated MHC genes in sticklebacks by having far fewer loci. Using European badgers (Meles meles), we therefore investigated whether innate immune activity, estimated functionally as the ability of an individual’s leukocytes to produce a respiratory burst, was influenced by MHC diversity. We also investigated whether LCC was influenced by factors such as age-class, sex, body condition, season, year, neutrophil and lymphocyte counts, and intensity of infection with five different pathogens. We found that LCC was not associated with specific MHC haplotypes, MHC alleles, or MHC diversity, indicating that the innate immune system did not compensate for the adaptive immune system even when there were susceptible MHC alleles/haplotypes, or when the MHC diversity was low. We also identified a seasonal and annual variation of LCC. This temporal variation of innate immunity was potentially due to physiological trade-offs or temporal variation in pathogen infections. The innate immunity, estimated as LCC, does not compensate for MHC diversity suggests that the immune system may function differently between vertebrates with different MHC organizations, with implications for the evolution of immune systems in different taxa.

Item Type: Article
Additional Information: © 2016 Sin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Faculty \ School: Faculty of Science
Faculty of Science > School of Biological Sciences
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Depositing User: Pure Connector
Date Deposited: 13 Oct 2016 14:00
Last Modified: 22 Apr 2020 01:50
URI: https://ueaeprints.uea.ac.uk/id/eprint/60920
DOI: 10.1371/journal.pone.0163773

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