The bacterial cytochrome cbb3 oxidases

Pitcher, Robert S. and Watmough, Nicholas J. (2004) The bacterial cytochrome cbb3 oxidases. Biochimica Et Biophysica Acta-Bioenergetics, 1655. pp. 388-399.

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Abstract

Cytochrome cbb3 oxidases are found almost exclusively in Proteobacteria, and represent a distinctive class of proton-pumping respiratory heme-copper oxidases (HCO) that lack many of the key structural features that contribute to the reaction cycle of the intensely studied mitochondrial cytochrome c oxidase (CcO). Expression of cytochrome cbb3 oxidase allows human pathogens to colonise anoxic tissues and agronomically important diazotrophs to sustain N2 fixation. We review recent progress in the biochemical characterisation of these distinctive oxidases that lays the foundation for understanding the basis of their proposed high affinity for oxygen, an apparent degeneracy in their electron input pathways and whether or not they acquired the ability to pump protons independently of other HCOs.

Item Type: Article
Faculty \ School: Faculty of Science > School of Biological Sciences
UEA Research Groups: Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry
Faculty of Science > Research Groups > Molecular Microbiology
Depositing User: EPrints Services
Date Deposited: 01 Oct 2010 13:37
Last Modified: 23 Jul 2024 05:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/608
DOI: 10.1016/j.bbabio.2003.09.017

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