Magnetic hyperthermia controlled drug release in the GI tract: solving the problem of detection

Bear, Joseph C., Patrick, P. Stephen, Casson, Alfred, Southern, Paul, Lin, Fang-Yu, Powell, Michael J., Pankhurst, Quentin A., Kalber, Tammy, Lythgoe, Mark, Parkin, Ivan P. and Mayes, Andrew G. (2016) Magnetic hyperthermia controlled drug release in the GI tract: solving the problem of detection. Scientific Reports, 6. ISSN 2045-2322

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Drug delivery to the gastrointestinal (GI) tract is highly challenging due to the harsh environments any drug- delivery vehicle must experience before it releases it’s drug payload. Effective targeted drug delivery systems often rely on external stimuli to effect release, therefore knowing the exact location of the capsule and when to apply an external stimulus is paramount. We present a drug delivery system for the GI tract based on coating standard gelatin drug capsules with a model eicosane- superparamagnetic iron oxide nanoparticle composite coating, which is activated using magnetic hyperthermia as an on-demand release mechanism to heat and melt the coating. We also show that the capsules can be readily detected via rapid X-ray computed tomography (CT) and magnetic resonance imaging (MRI), vital for progressing such a system towards clinical applications. This also offers the opportunity to image the dispersion of the drug payload post release. These imaging techniques also influenced capsule content and design and the delivered dosage form. The ability to easily change design demonstrates the versatility of this system, a vital advantage for modern, patient-specific medicine.

Item Type: Article
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Faculty \ School: Faculty of Science > School of Chemistry
UEA Research Groups: Faculty of Science > Research Groups > Physical and Analytical Chemistry (former - to 2017)
Faculty of Science > Research Groups > Chemistry of Materials and Catalysis
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Depositing User: Pure Connector
Date Deposited: 04 Oct 2016 12:03
Last Modified: 22 Oct 2022 01:39
DOI: 10.1038/srep34271


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