Chitin butyrate coated electrospun nylon-6 fibers for biomedical applications

Pant, Hem Raj, Kim, Han Joo, Bhatt, Lok Ranjan, Joshi, Mahesh Kumar, Kim, Eun Kyo, Kim, Jeong In, Abdal-Hay, Abdalla, Hui, K. S. ORCID: and Kim, Cheol Sang (2013) Chitin butyrate coated electrospun nylon-6 fibers for biomedical applications. Applied Surface Science, 285 (Part B). pp. 538-544. ISSN 0169-4332

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In this study, we describe the preparation and characterizations of chitin butyrate (CB) coated nylon-6 nanofibers using single-spinneret electrospinning of blends solution. The physicochemical properties of nylon-6 composite fibers with different proportions of CB to nylon-6 were determined using FE-SEM, TEM, FT-IR spectroscopy, and water contact angle measurement. FE-SEM and TEM images revealed that the nylon-6 and CB were immiscible in the as-spun nanofibers, and phase separated nanofiber morphology becomes more pronounced with increasing amounts of CB. The bone formation ability of composite fibers was evaluated by incubating in biomimetic simulated body fluid. In order to assay the cytocompatibility and cell behavior on the composite scaffolds, osteoblast cells were seeded on the matrix. Results suggest that the deposition of CB layer on the surface of nylon-6 could increase its cell compatibility and bone formation ability. Therefore, as-synthesized nanocomposite fibrous mat has great potentiality in hard tissue engineering.

Item Type: Article
Uncontrolled Keywords: biomaterials,chitin butyrate,electrospinning,nanofibers,nylon-6
Faculty \ School: Faculty of Science > School of Mathematics
UEA Research Groups: Faculty of Science > Research Groups > Energy Materials Laboratory
Related URLs:
Depositing User: Pure Connector
Date Deposited: 30 Sep 2016 16:00
Last Modified: 22 Oct 2022 01:36
DOI: 10.1016/j.apsusc.2013.08.089

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