The effect of increasing physical activity and/or omega-3 supplementation on fatigue in inflammatory bowel disease

McNelly, Angela S., Nathan, Indira, Monti, Marilina, Grimble, George K., Norton, Christine, Bredin, Frances, Czuber-Dochan, Wladyslawa J., Berliner, Stuart, Gay, Martin A., Darvell, Marcia, Terry, Helen and Forbes, Alastair (2016) The effect of increasing physical activity and/or omega-3 supplementation on fatigue in inflammatory bowel disease. Gastrointestinal Nursing, 14 (8). pp. 39-50. ISSN 1479-5248

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Objective: Fatigue is frequently reported by patients with inflammatory bowel disease (IBD), irrespective of disease activity; however, evidence regarding fatigue management is limited. This study tested the effect of individualised advice to increase physical activity and/or omega-3 fatty acids supplementation, on IBD-related fatigue. Methods: A pilot study in patients with inactive IBD, utilising a randomised controlled 2x2 factorial design (four groups) compared baseline and post-intervention fatigque scores. Study interventions: individualised exercise advice (15 minute consultation) and/or supplementation (omega-3 fatty acids, 2970mg/day) for 12 weeks. Control interventions: general health discussion and/or placebo supplement. All patients received follow-up support. Primary outcome was fatigue measured by Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale score; secondary outcomes included change in Inflammatory Bowel Disease-Fatigue (IBD-F) scale score. Results: From n=656 screened patients, n=74 who met the selection criteria were randomised, n=60 commenced, and n=52 completed the study. Fatigue as tThe primary outcome fatigque, measured with FACIT-F, showed slight worsening in the omega-3 supplementation group (95%CI:-8.6-(-0.7);p=0.02), and no change in the exercise advice group (p=0.38). Reduced fatigue, measured by IBD-F score, was identified in the exercise group (95%CI:-3.8-(-0.2);p=0.03). One treatment-related adverse event (musculoskeletal pain) was reported with exercise. Conclusions: Advice to increase physical activity and omega-3 supplementation, singly or in combination, were shown to be safe and generally well-tolerated. There was no evidence of exercise-related adverse effects on gut-related symptoms, and some evidence of improvement in fatigue. The slight worsening of fatigue with omega-3 supplementation is unexplained. Regular moderate to -vigorous exercise may be a self-management option in IBD-related fatigue.

Item Type: Article
Additional Information: Early title: A randomised controlled pilot study investigating the effect of increasing physical activity and/or omega-3 supplementation on fatigue in patients with inflammatory bowel disease
Uncontrolled Keywords: fatigue,nutrition,omega-3 supplementation,physical activity,ibd
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Pure Connector
Date Deposited: 30 Sep 2016 15:00
Last Modified: 17 Apr 2022 00:11
DOI: 10.12968/gasn.2016.14.8.39

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