Nutrition for the ageing brain: towards evidence for an optimal diet

Vauzour, David ORCID: https://orcid.org/0000-0001-5952-8756, Camprubi Robles, Maria, Miquel-Kergoat, Sophie, Andres-Lacueva, Cristina, Bánáti, Diána, Barberger-Gateau, Pascale, Bowman, Gene L., Caberlotto, Laura, Clarke, Robert, Hogervorst, Eef, Kiliaan, Amanda J., Lucca, Ugo, Manach, Claudine, Minihane, Anne-Marie ORCID: https://orcid.org/0000-0001-9042-4226, Mitchell, Ellen Siobhan, Perneczky, Robert, Perry, Hugh, Roussel, Anne-Marie, Schuermans, Jeroen, Sijben, John, Spencer, Jeremy P. E., Thuret, Sandrine, van de Rest, Ondine, Vandewoude, Maurits, Wesnes, Keith, Williams, Robert J., Williams, Robin S. B. and Ramirez, Maria (2017) Nutrition for the ageing brain: towards evidence for an optimal diet. Ageing Research Reviews, 35. 222–240. ISSN 1568-1637

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Abstract

As people age they become increasingly susceptible to chronic and extremely debilitating brain diseases. The precise cause of the neuronal degeneration underlying these disorders, and indeed normal brain ageing remains however elusive. Considering the limits of existing preventive methods, there is a desire to develop effective and safe strategies. Growing preclinical and clinical research in healthy individuals or at the early stage of cognitive decline has demonstrated the beneficial impact of nutrition on cognitive functions. The present review is the most recent in a series produced by the Nutrition and Mental Performance Task Force under the auspice of the International Life Sciences Institute Europe (ILSI Europe). The latest scientific advances specific to how dietary nutrients and non-nutrient may affect cognitive ageing are presented. Furthermore, several key points related to mechanisms contributing to brain ageing, pathological conditions affecting brain function, and brain biomarkers are also discussed. Overall, findings are inconsistent and fragmented and more research is warranted to determine the underlying mechanisms and to establish dose-response relationships for optimal brain maintenance in different population subgroups. Such approaches are likely to provide the necessary evidence to develop research portfolios that will inform about new dietary recommendations on how to prevent cognitive decline.

Item Type:	Article
Additional Information:	Under a Creative Commons license
Uncontrolled Keywords:	cognition,preventive diet,cognitive decline,neuroprotection,neuroinflammation,cognitive ageing
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
Depositing User:	Pure Connector
Date Deposited:	30 Sep 2016 15:00
Last Modified:	19 Oct 2023 01:47
URI:	https://ueaeprints.uea.ac.uk/id/eprint/60639
DOI:	10.1016/j.arr.2016.09.010

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