A Clinical, Biological, and Biomaterials Perspective into Tendon Injuries and Regeneration

Walden, Grace, Liao, Xin, Donell, Simon, Raxworthy, Mike J, Riley, Graham and Saeed, Aram (2017) A Clinical, Biological, and Biomaterials Perspective into Tendon Injuries and Regeneration. Tissue Engineering Part B: Reviews, 23 (1). pp. 44-58. ISSN 2152-4947

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Abstract

Tendon injury is common and debilitating, and it is associated with long-term pain and ineffective healing. It is estimated to afflict 25% of the adult population and is often a career-ending disease in athletes and racehorses. Tendon injury is associated with high morbidity, pain, and long-term suffering for the patient. Due to the low cellularity and vascularity of tendon tissue, once damage has occurred, the repair process is slow and inefficient, resulting in mechanically, structurally, and functionally inferior tissue. Current treatment options focus on pain management, often being palliative and temporary and ending in reduced function. Most treatments available do not address the underlying cause of the disease and, as such, are often ineffective with variable results. The need for an advanced therapeutic that addresses the underlying pathology is evident. Tissue engineering and regenerative medicine is an emerging field that is aimed at stimulating the body's own repair system to produce de novo tissue through the use of factors such as cells, proteins, and genes that are delivered by a biomaterial scaffold. Successful tissue engineering strategies for tendon regeneration should be built on a foundation of understanding of the molecular and cellular composition of healthy compared with damaged tendon, and the inherent differences seen in the tissue after disease. This article presents a comprehensive clinical, biological, and biomaterials insight into tendon tissue engineering and regeneration toward more advanced therapeutics.

Item Type: Article
Uncontrolled Keywords: tendon injury,tissue engineering,tendinopathy,tendon rupture,injectable scaffold,implant
Faculty \ School: Faculty of Science > School of Pharmacy
Faculty of Science
Faculty of Medicine and Health Sciences > Norwich Medical School

Faculty of Science > School of Biological Sciences
Depositing User: Pure Connector
Date Deposited: 28 Sep 2016 14:00
Last Modified: 31 Oct 2019 14:58
URI: https://ueaeprints.uea.ac.uk/id/eprint/60622
DOI: 10.1089/ten.TEB.2016.0181

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