Upconversion nanomaterials for photodynamic therapy

Marin Altaba, Maria ORCID: https://orcid.org/0000-0001-8021-5498 and Russell, David (2016) Upconversion nanomaterials for photodynamic therapy. In: Near-infrared Nanomaterials: Preparation, Bioimaging and Therapy Applications. Nanoscience and Nanotechnology (1st). Royal Society of Chemistry, pp. 192-231. ISBN 978-1-78262-319-9

Full text not available from this repository. (Request a copy)


Photodynamic therapy (PDT) is an innovative treatment where cancerous tumors are destroyed by the reactive oxygen species generated by photosensitizer drugs following activation with light typically of visible wavelengths. However, such visible light has limited penetration depth through skin and other healthy tissues, so deep-lying tumors can be difficult to treat. Upconversion nanoparticles (UCNPs) can be used as photosensitizer nanocarriers to overcome the limitation of visible light excitation. Near infrared (NIR) light has significantly deeper penetration depth than visible light through human tissue and can be used to excite the UCNPs that then emit light at shorter wavelengths. The emission of the UCNPs overlaps with the absorption band of the vast majority of currently used photosensitizers. Thus, the upconversion luminescence emitted by the UCNPs can be used to excite the photosensitizer bound in close proximity to the nanoparticles, inducing the generation of reactive oxygen species and thereby killing the cancer cells. This chapter introduces the proof of concept in the use of UCNPs for PDT and provides an insight into the state-of-art use of these nanomaterials for both in vitro and in vivo PDT.

Item Type: Book Section
Uncontrolled Keywords: sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Science > School of Chemistry
UEA Research Groups: Faculty of Science > Research Groups > Chemistry of Materials and Catalysis
Related URLs:
Depositing User: Pure Connector
Date Deposited: 24 Sep 2016 01:03
Last Modified: 21 Oct 2022 23:55
URI: https://ueaeprints.uea.ac.uk/id/eprint/60434
DOI: 10.1039/9781782623939-00192

Actions (login required)

View Item View Item