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Evans, Benjamin A 
ORCID: https://orcid.org/0000-0001-6849-9758, Hamouda, Ahmed and Amyes, Sebastian G B
(2007)
OXA-type β-lactamases in Acinetobacter baumannii: emerging from the shadow of the extended-spectrum β-lactamases.
Reviews in Medical Microbiology, 18 (4).
pp. 63-72.
ISSN 0954-139X
Abstract
The extended-spectrum β-lactamases have evolved owing to the extensive use of the oxyimino-cephalosporins, and have greatly reduced the treatment options for serious infections. Acinetobacter baumannii is becoming an increasingly important multiresistant nosocomial pathogen due to the carriage of class D OXA-type β-lactamases. The OXA-23-like, OXA-40-like and OXA-58-like β-lactamases confer carbapenem resistance and are increasingly being found in association with a diversity of mobile genetic elements. High prevalence of OXA-40-like enzymes on the Iberian Peninsula, OXA-58-like enzymes across Europe and very high prevalence of OXA-23-like enzymes in South America and Asia are of concern. The intrinsic OXA-51-like enzymes of A. baumannii may confer carbapenem resistance when overexpressed, and form a large enzyme family. Similar patterns are beginning to be seen for the OXA-type β-lactamases, which were previously seen in the emergence of the extended-spectrum β-lactamases, the continuation of which would pose a grave threat to the antibiotic era.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Depositing User: | Pure Connector |
| Date Deposited: | 24 Sep 2016 00:29 |
| Last Modified: | 19 Oct 2023 01:45 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/60064 |
| DOI: | 10.1097/MRM.0b013e3282fce3d2 |
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