Heart failure following cancer treatment: characteristics, survival and mortality of a linked health data analysis

Clark, R. A., Berry, N. M., Chowdhury, M. H., McCarthy, A. L., Ullah, S., Versace, V. L., Atherton, J. J., Koczwara, B. and Roder, D. (2016) Heart failure following cancer treatment: characteristics, survival and mortality of a linked health data analysis. Internal Medicine Journal, 46 (11). 1297–1306. ISSN 1445-5994

[thumbnail of Accepted manuscript]
PDF (Accepted manuscript) - Accepted Version
Download (361kB) | Preview


Background: Cardiotoxicity resulting in heart failure is a devastating complication of cancer therapy. A patient may survive cancer only to develop heart failure (HF), which has a higher mortality rate than some cancers. Aim: This study aimed to describe the characteristics and outcomes of HF in patients with blood or breast cancer after chemotherapy treatment. Methods: Queensland Cancer Registry, Death Registry and Hospital Administration records were linked (1996–2009). Patients were categorised as those with an index HF admission (that occurred after cancer diagnosis) and those without an index HF admission (non-HF). Results: A total of 15 987 patients was included, and 1062 (6.6%) had an index HF admission. Median age of HF patients was 67 years (interquartile range 58–75) versus 54 years (interquartile range 44–64) for non-HF patients. More men than women developed HF (48.6% vs 29.5%), and a greater proportion in the HF group had haematological cancer (83.1%) compared with breast cancer (16.9%). After covariate adjustment, HF patients had increased mortality risk compared with non-HF patients (hazard ratios 1.67 (95% confidence interval, 1.54–1.81)), and 47% of the index HF admission occurred within 1 year from cancer diagnosis and 70% within 3 years. Conclusion: Cancer treatment may place patients at a greater risk of developing HF. The onset of HF occurred soon after chemotherapy, and those who developed HF had a greater mortality risk.

Item Type: Article
Uncontrolled Keywords: cardiotoxicity,heart failure,chemotherapy,cardiology,oncology,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:
Depositing User: Pure Connector
Date Deposited: 24 Sep 2016 00:16
Last Modified: 22 Oct 2022 01:24
URI: https://ueaeprints.uea.ac.uk/id/eprint/59959
DOI: 10.1111/imj.13201

Actions (login required)

View Item View Item