The People with Asperger syndrome and anxiety disorders (PAsSA) trial: A pilot multicentre, single-blind randomised trial of group cognitive–behavioural therapy

Langdon, Peter, Murphy, Glynis, Shepstone, Lee, Wilson, Edward, Fowler, David, Heavens, David, Malovic, Aida, Russell, Alexandra, Rose, Alice and Mullineaux, Louise (2016) The People with Asperger syndrome and anxiety disorders (PAsSA) trial: A pilot multicentre, single-blind randomised trial of group cognitive–behavioural therapy. BJPsych Open, 2 (2). pp. 179-186.

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Abstract

Background: There is a growing interest in using cognitive–behavioural therapy (CBT) with people who have Asperger syndrome and comorbid mental health problems. Aims: To examine whether modified group CBT for clinically significant anxiety in an Asperger syndrome population is feasible and likely to be efficacious. Method: Using a randomised assessor-blind trial, 52 individuals with Asperger syndrome were randomised into a treatment arm or a waiting-list control arm. After 24 weeks, those in the waiting-list control arm received treatment, while those initially randomised to treatment were followed up for 24 weeks. Results: The conversion rate for this trial was high (1.6:1), while attrition was 13%. After 24 weeks, there was no significant difference between those randomised to the treatment arm compared with those randomised to the waiting-list control arm on the primary outcome measure, the Hamilton Rating Scale for Anxiety. Conclusions: Trials of psychological therapies with this population are feasible. Larger definitive trials are now needed.

Item Type:	Article
Additional Information:	© 2016 The Royal College of Psychiatrists This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) licence (http://creativecommons.org/licenses/by/4.0/).
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Population Health Faculty of Science > Research Groups > Statistics
Depositing User:	Pure Connector
Date Deposited:	24 Sep 2016 00:10
Last Modified:	30 Jun 2025 00:22
URI:	https://ueaeprints.uea.ac.uk/id/eprint/59891
DOI:	10.1192/bjpo.bp.115.002527

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