OXA-51-like β-lactamases and their association with particular epidemic lineages of Acinetobacter baumannii

Evans, B A, Hamouda, A, Towner, K J and Amyes, S G B (2008) OXA-51-like β-lactamases and their association with particular epidemic lineages of Acinetobacter baumannii. Clinical Microbiology and Infection, 14 (3). pp. 268-275. ISSN 1198-743X

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Abstract

Sixty diverse clinical Acinetobacter baumannii isolates of worldwide origin were assigned to sequence groups, based on a multiplex PCR for the ompA, csuE and bla(OXA-51-like) genes. The majority (77%) of isolates belonged to sequence groups 1 and 2 (SG1 and SG2), with sequence group 3 (SG3) and non-grouped isolates accounting for the remainder. The isolates were not closely related according to pulsed-field gel electrophoresis (PFGE), and the majority were sensitive to imipenem and meropenem. The construction of a linkage map of OXA-51-like beta-lactamase sequence relationships revealed two closely related clusters of enzymes, one focused around OXA-66 and the other around OXA-69. Isolates belonging to SG1 encoded an enzyme from the OXA-66 cluster, while those belonging to SG2 encoded an enzyme from the OXA-69 cluster. All SG3 isolates encoded OXA-71, which does not form part of a close enzyme grouping. Major multinational lineages accounted for a significant proportion of A. baumannii clinical isolates, and the evolution of the OXA-51-like enzymes appears to be an ongoing process.

Item Type: Article
Uncontrolled Keywords: acinetobacter baumannii,blaoxa-51-like,carbapenemase,lineages,linkage map,sequence groups
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 24 Sep 2016 00:09
Last Modified: 22 Apr 2020 01:35
URI: https://ueaeprints.uea.ac.uk/id/eprint/59874
DOI: 10.1111/j.1469-0691.2007.01919.x

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