Syntactic comprehension deficits across the FTD-ALS continuum

Kamminga, Jody, Leslie, Felicity V.C., Hsieh, Sharpley, Caga, Jashelle, Mioshi, Eneida, Hornberger, Michael ORCID: https://orcid.org/0000-0002-2214-3788, Ballard, Kirrie J., Kiernan, Matthew C., Hodges, John R. and Burrell, James R. (2016) Syntactic comprehension deficits across the FTD-ALS continuum. Neurobiology of Aging, 41. pp. 11-18. ISSN 0197-4580

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Abstract

To establish the frequency, severity, relationship to bulbar symptoms, and neural correlates of syntactic comprehension deficits across the frontotemporal dementia–amyotrophic lateral sclerosis (FTD-ALS) disease spectrum. In total, 85 participants were included in the study; 20 amyotrophic lateral sclerosis (ALS), 15 FTD-ALS, 27 progressive nonfluent aphasia (PNFA), and 23 controls. Syntactic comprehension was evaluated in ALS, FTD-ALS, PNFA, and controls using the Test for Reception of Grammar. Voxel-based morphometry examined neuroanatomical correlates of performance. Syntactic comprehension deficits were detected in 25% of ALS (p = 0.011), 92.9% of FTD-ALS (p < 0.001), and 81.5% of PNFA (p < 0.001) patients. FTD-ALS was disproportionately impaired compared to PNFA. Impaired Test for Reception of Grammar performance was frequent in ALS with early bulbar involvement but did not correlate with bulbar impairment overall. Left peri-insular atrophy correlated with syntactic comprehension deficits. Syntactic comprehension deficits are frequent in FTD-ALS, more severe than in PNFA, and related to left peri-insular atrophy. A significant minority of ALS patients are impaired, but the relationship between bulbar symptoms and syntactic impairment is not understood.

Item Type: Article
Uncontrolled Keywords: ftd-als continuum,cognitive impairment,syntactic comprehension deficits
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Mental Health
Faculty of Medicine and Health Sciences > Research Groups > Dementia & Complexity in Later Life
Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
Depositing User: Pure Connector
Date Deposited: 24 Sep 2016 00:09
Last Modified: 19 Oct 2023 01:44
URI: https://ueaeprints.uea.ac.uk/id/eprint/59859
DOI: 10.1016/j.neurobiolaging.2016.02.002

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