Regulation of pattern recognition receptor signalling in plants

Couto, Daniel and Zipfel, Cyril (2016) Regulation of pattern recognition receptor signalling in plants. Nature Reviews Immunology, 16 (9). 537–552. ISSN 1474-1733

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Recognition of pathogen-derived molecules by pattern recognition receptors (PRRs) is a common feature of both animal and plant innate immune systems. In plants, PRR signalling is initiated at the cell surface by kinase complexes, resulting in the activation of immune responses that ward off microbes. However, the activation and amplitude of innate immune responses must be tightly controlled. In this Review, we summarize our knowledge of the early signalling events that follow PRR activation, and describe the mechanisms that fine-tune immune signalling to maintain immune homeostasis. We also illustrate the mechanisms used by pathogens to inhibit innate immune signalling, and discuss how the innate ability of plant cells to monitor the integrity of key immune components can lead to autoimmune phenotypes upon genetic or pathogen-induced perturbations of these components.

Item Type: Article
Additional Information: Funding Information: D.C. was supported by a Ph.D. scholarship (reference SFRH/BD/79088/2011) from Fundação para a Ciência e a Tecnologia (FCT). Research in the Zipfel laboratory is funded by the Gatsby Charitable Foundation, the European Research Council (ERC), the UK Biotechnology and Biological Sciences Research Council (BBSRC), and the Two Blades Foundation.
Faculty \ School: Faculty of Science > The Sainsbury Laboratory
Faculty of Science > School of Biological Sciences
UEA Research Groups: Faculty of Science > Research Groups > Plant Sciences
Depositing User: Pure Connector
Date Deposited: 16 Jun 2016 15:00
Last Modified: 05 Apr 2023 15:31
DOI: 10.1038/nri.2016.77


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