Effector specialization in a lineage of the Irish potato famine pathogen

Dong, Suomeng, Stam, Remco, Cano, Liliana M., Song, Jing, Sklenar, Jan, Yoshida, Kentaro, Bozkurt, Tolga O., Oliva, Ricardo, Liu, Zhenyu, Tian, Miaoying, Win, Joe, Banfield, Mark J., Jones, Alexandra M E, Van Der Hoorn, Renier A L and Kamoun, Sophien (2014) Effector specialization in a lineage of the Irish potato famine pathogen. Science, 343 (6170). pp. 552-555. ISSN 0036-8075

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Abstract

Accelerated gene evolution is a hallmark of pathogen adaptation following a host jump. Here, we describe the biochemical basis of adaptation and specialization of a plant pathogen effector after its colonization of a new host. Orthologous protease inhibitor effectors from the Irish potato famine pathogen, Phytophthora infestans, and its sister species, Phytophthora mirabilis, which is responsible for infection of Mirabilis jalapa, are adapted to protease targets unique to their respective host plants. Amino acid polymorphisms in both the inhibitors and their target proteases underpin this biochemical specialization. Our results link effector specialization to diversification and speciation of this plant pathogen.

Item Type: Article
Faculty \ School:


Faculty of Science > School of Biological Sciences
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Depositing User: Pure Connector
Date Deposited: 06 Jun 2016 16:01
Last Modified: 22 Apr 2020 01:28
URI: https://ueaeprints.uea.ac.uk/id/eprint/59241
DOI: 10.1126/science.1246300

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