Plasma C-peptide concentration in women with Type 1 diabetes during early and late pregnancy

Murphy, H R, Elleri, D, Allen, J M, Simmons, D, Nodale, M and Hovorka, R (2012) Plasma C-peptide concentration in women with Type 1 diabetes during early and late pregnancy. Diabetic Medicine, 29 (10). e361-4. ISSN 0742-3071

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Abstract

AIMS: There are previous suggestions of increased C-peptide concentration in women with Type 1 diabetes during pregnancy. Our aim was to re-evaluate the hypothesis of a pregnancy-induced increase by measuring plasma C-peptide concentration in women with stable blood glucose control under standardized fasting and meal-stimulated conditions. METHODS: Ten women with Type 1 diabetes; median age 31.1 years, median diabetes duration 19 years, median HbA(1c) 52 mmol/mol (6.9%) were admitted to a clinical research facility for two 24-h visits in early (12-16 weeks) and late (28-32 weeks) pregnancy. Women They ate standardized study meals - 80-g carbohydrate dinner, 60-g carbohydrate breakfast, and fasted between meals and overnight. Closed-loop insulin delivery maintained stable and comparable glycaemic conditions. Paired samples for plasma glucose and C-peptide were obtained. RESULTS: Plasma glucose levels were comparable in early (median 6.5 mmol/l; interquartile range 5.6-8.6) and late pregnancy (median 7.0 mmol/l; interquartile range 6.1-7.8; P = 0.72). There was no change in fasting or meal-stimulated plasma C-peptide concentration from early to late pregnancy; mean difference 4.0 pmol/l (95% CI -6.0 to 7.0; P = 0.9). Four women had detectable C-peptide; peak (range) early vs. late pregnancy 48.5 (10-115) vs. 40.0 pmol/l (80-105); P = 0.5, which was weakly associated with plasma glucose; R(2) = 0.15, P < 0.0001. CONCLUSIONS: We found no gestational changes in plasma C-peptide concentration. Previously reported increases may reflect differences in glucose control and/or exogenous insulin doses. This study highlights the importance and challenges of standardizing experimental conditions for accurate plasma C-peptide measurement during Type 1 diabetes pregnancy.

Item Type: Article
Additional Information: © 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK.
Uncontrolled Keywords: adult,blood glucose,c-peptide,diabetes mellitus type 1,fasting,female,hemoglobin a glycosylated,humans,hypoglycemic agents,insulin,meals,pregnancy,pregnancy trimester (first),pregnancy trimester (third),pregnancy in diabetics
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 25 May 2016 13:00
Last Modified: 22 Apr 2020 01:26
URI: https://ueaeprints.uea.ac.uk/id/eprint/59053
DOI: 10.1111/j.1464-5491.2012.03747.x

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