Processing-Induced Disorder in Pharmaceutical Materials

Qi, Sheng (2016) Processing-Induced Disorder in Pharmaceutical Materials. In: Disordered Pharmaceutical Materials. Wiley, pp. 467-491. ISBN 9783527331253

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Abstract

This chapter focuses on the major types of pharmaceutical processing methods that have been widely reported to produce disordered material either intentionally or unintentionally. Milling is one of the most frequently used unit operations used by the pharmaceutical industry for reducing the particle size of solids. Thermal processing techniques are mainly used for controlling or improving the release and the subsequent bioavailability of an active pharmaceutical ingredient (API). Techniques such as melt-mixing, spray-congealing, sintering, melt-granulation, and hot-melt extrusion (HME) have developed and evolved rapidly for large-scale pharmaceutical production. Solvent-evaporation-based methods are important processing techniques for both raw materials, such as crystallization of the raw drug, and formulation manufacturing in the pharmaceutical industry. The chapter discusses the processing that can potentially induce the formation of the disordered state during the manufacture of formulations. The widely used solvent-evaporation-based processing techniques in pharmaceutical formulation production include spray-drying, freeze-drying, film casting, and film coating.

Item Type: Book Section
Faculty \ School: Faculty of Science > School of Pharmacy
Related URLs:
Depositing User: Pure Connector
Date Deposited: 24 May 2016 11:00
Last Modified: 31 Oct 2019 16:17
URI: https://ueaeprints.uea.ac.uk/id/eprint/59036
DOI: 10.1002/9783527652693.ch15

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