An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor

Dagdas, Yasin F, Belhaj, Khaoula, Maqbool, Abbas, Chaparro-Garcia, Angela, Pandey, Pooja, Petre, Benjamin, Tabassum, Nadra, Cruz-Mireles, Neftaly, Hughes, Richard K, Sklenar, Jan, Win, Joe, Menke, Frank ORCID: https://orcid.org/0000-0003-2490-4824, Findlay, Kim, Banfield, Mark J, Kamoun, Sophien ORCID: https://orcid.org/0000-0002-0290-0315 and Bozkurt, Tolga O (2016) An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor. eLife, 5. ISSN 2050-084X

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Abstract

Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate autophagosome formation. PexRD54 depletes the autophagy cargo receptor Joka2 out of ATG8CL complexes and interferes with Joka2's positive effect on pathogen defense. Thus, a plant pathogen effector has evolved to antagonize a host autophagy cargo receptor to counteract host defenses.

Item Type:	Article
Additional Information:	© 2016, Dagdas et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Science > School of Biological Sciences Faculty of Science > The Sainsbury Laboratory
UEA Research Groups:	Faculty of Science > Research Groups > Plant Sciences
Depositing User:	Pure Connector
Date Deposited:	19 May 2016 09:00
Last Modified:	22 Oct 2022 01:09
URI:	https://ueaeprints.uea.ac.uk/id/eprint/58881
DOI:	10.7554/eLife.10856

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