Negative BOLD response in the hippocampus during short-term spatial memory retrieval

Nilsson, Jonna, Ferrier, I. Nicol, Coventry, Kenny, Bester, Andre and Finkelmeyer, Andreas (2013) Negative BOLD response in the hippocampus during short-term spatial memory retrieval. Journal of Cognitive Neuroscience, 25 (8). pp. 1358-1371. ISSN 0898-929X

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Abstract

A parieto-medial temporal pathway is thought to underlie spatial navigation in humans. fMRI was used to assess the role of this pathway, including the hippocampus, in the cognitive processes likely to underlie navigation based on environmental cues. Participants completed a short-term spatial memory task in virtual space, which required no navigation but involved the recognition of a target location from a foil location based on environmental landmarks. The results showed that spatial memory retrieval based on environmental landmarks was indeed associated with increased signal in regions of the parietomedial temporal pathway, including the superior parietal cortex, the retrosplenial cortex, and the lingual gyrus. However, the hippocampus demonstrated a signal decrease below the fixation baseline during landmark-based retrieval, whereas there was no signal change from baseline during retrieval based on viewer position. In a discussion of the origins of such negative BOLD response in the hippocampus, we consider both a suppression of default activity and an increase in activity without a corresponding boost in CBF as possible mechanisms.

Item Type: Article
Faculty \ School: Faculty of Social Sciences > School of Psychology
Related URLs:
Depositing User: Pure Connector
Date Deposited: 17 May 2016 15:00
Last Modified: 21 Apr 2020 22:11
URI: https://ueaeprints.uea.ac.uk/id/eprint/58797
DOI: 10.1162/jocn_a_00396

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