Emergence of an imaging biomarker for amyotrophic lateral sclerosis: is the end point near?

Hornberger, Michael and Kiernan, Matthew C. (2016) Emergence of an imaging biomarker for amyotrophic lateral sclerosis: is the end point near? Journal of Neurology, Neurosurgery and Psychiatry, 87 (6). ISSN 0022-3050

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Abstract

A diagnostic and treatment biomarker for amyotrophic lateral sclerosis (ALS) remains a holy grail.1 ,2 From a neuroimaging perspective, diffusion tensor imaging (DTI) has been increasingly utilised to identify brain-related upper motor neuron changes in ALS. In particular, the corticospinal tract, anterior corpus callosum and hippocampal fractional anisotropy (FA) white matter changes have been closely linked with ALS pathology3 ,4 and associated with the underlying neuropathological spread of TAR DNA binding protein 43 (TDP-43).5 Thus, DTI emerges as an ideal neuroimaging biomarker end point for disease-modifying trials in ALS. However, most advanced trials are run on a multicentre basis, and currently it is not clear how DTI signatures across centres in ALS hold-up, in particular with varying imaging sequences and scanner variabilities.

Item Type: Article
Additional Information: This article has been accepted for publication in Journal of Neurology, Neurosurgery and Psychiatry following peer review. The definitive copyedited, typeset version "Emergence of an imaging biomarker for amyotrophic lateral sclerosis: is the end point near?" by Michael Hornberger, Matthew C Kiernan, J Neurol Neurosurg Psychiatry 2016;87:6 569 Published Online First: 29 February 2016 doi:10.1136/jnnp-2015-312882 is available online at: http://jnnp.bmj.com/content/87/6/569
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 01 Apr 2016 10:13
Last Modified: 28 Oct 2019 14:05
URI: https://ueaeprints.uea.ac.uk/id/eprint/58041
DOI: 10.1136/jnnp-2015-312882

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