Genome-wide association study of response to cognitive–behavioural therapy in children with anxiety disorders

Coleman, Jonathan R. I., Lester, Kathryn J., Keers, Robert, Roberts, Susanna, Curtis, Charles, Arendt, Kristian, Bögels, Susan, Cooper, Peter, Creswell, Cathy, Dalgleish, Tim, Hartman, Catharina A., Heiervang, Einar R., Hötzel, Katrin, Hudson, Jennifer L., In-Albon, Tina, Lavallee, Kristen, Lyneham, Heidi J., Marin, Carla E., Meiser-Stedman, Richard ORCID:, Morris, Talia, Nauta, Maaike H., Rapee, Ronald M., Schneider, Silvia, Schneider, Sophie C., Silverman, Wendy K., Thastum, Mikael, Thirlwall, Kerstin, Waite, Polly, Wergeland, Gro Janne, Breen, Gerome and Eley, Thalia C. (2016) Genome-wide association study of response to cognitive–behavioural therapy in children with anxiety disorders. The British Journal of Psychiatry, 209 (3). pp. 236-243. ISSN 1472-1465

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Background: Anxiety disorders are common, and cognitive–behavioural therapy (CBT) is a first-line treatment. Candidate gene studies have suggested a genetic basis to treatment response, but findings have been inconsistent. Aims: To perform the first genome-wide association study (GWAS) of psychological treatment response in children with anxiety disorders (n = 980). Method: Presence and severity of anxiety was assessed using semi-structured interview at baseline, on completion of treatment (post-treatment), and 3 to 12 months after treatment completion (follow-up). DNA was genotyped using the Illumina Human Core Exome-12v1.0 array. Linear mixed models were used to test associations between genetic variants and response (change in symptom severity) immediately post-treatment and at 6-month follow-up. Results: No variants passed a genome-wide significance threshold (P = 5×10−8) in either analysis. Four variants met criteria for suggestive significance (P<5×10−6) in association with response post-treatment, and three variants in the 6-month follow-up analysis. Conclusions: This is the first genome-wide therapygenetic study. It suggests no common variants of very high effect underlie response to CBT. Future investigations should maximise power to detect single-variant and polygenic effects by using larger, more homogeneous cohorts.

Item Type: Article
Additional Information: © The Royal College of Psychiatrists 2016. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) licence.
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Mental Health
Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
Depositing User: Pure Connector
Date Deposited: 22 Mar 2016 09:17
Last Modified: 19 Oct 2023 01:33
DOI: 10.1192/bjp.bp.115.168229


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