Impact of genotype on EPA and DHA status and responsiveness to increased intakes

Minihane, Anne-Marie ORCID: (2016) Impact of genotype on EPA and DHA status and responsiveness to increased intakes. Nutrients, 8 (3). ISSN 2072-6643

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At a population level, cardioprotective and cognitive actions of the fish oil (FO) derived long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been extensively demonstrated. In addition to dietary intake, which is limited for many individuals, EPA and DHA status is dependent on the efficiency of their biosynthesis from α-linolenic acid. Gender and common gene variants have been identified as influencing the rate-limiting desaturase and elongase enzymes. Response to a particular intake or status is also highly heterogeneous and likely influenced by genetic variants which impacts on EPA and DHA metabolism and tissue partitioning, transcription factor activity, or physiological end-point regulation. Here available literature relating genotype to tissue LC n-3 PUFA status and response to FO intervention is considered. It is concluded that the available evidence is relatively limited, with much of the variability unexplained, though APOE and FADS genotypes are emerging as being important. Although numerous genotype × LC-n3 PUFA × phenotype associations have been described, few have been confirmed in independent studies. A more comprehensive understanding of the genetic, physiological and behavioural modulators of EPA and DHA status and response to intervention is needed to allow refinement of current dietary LC n-3 PUFA recommendations and stratification of advice to ‘vulnerable’ and responsive subgroups.

Item Type: Article
Additional Information: This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: eicosapentaenoic acid,epa,docosahexaenoic acid,dha,long chain n-3 pufa,genotype,apoe,fads
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
Depositing User: Pure Connector
Date Deposited: 17 Mar 2016 12:01
Last Modified: 19 Oct 2023 01:38
DOI: 10.3390/nu8030123


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