Impact of lymph node ratio in the colorectal cancer staging system

Del Rio, Paolo, Dell'Abate, Paolo, Papadia, Cinzia, Angeletta, Adriana, Montana, Chiara, Iapichino, Gioacchino and Sianesi, Mario (2012) Impact of lymph node ratio in the colorectal cancer staging system. Annali Italiani di Chirurgia, 83 (5). pp. 399-403. ISSN 0003-469X

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Abstract

AIM: Some researchers have proposed the Lymph Node Ratio (LNR) as a prognostic index for post-surgical colorectal cancer follow up.  MATERIAL AND METHOD: Two hundred patients with colorectal cancer (ratio F/M of 2:1) were studied. Patients were divided in subgroups according to N-stage and LNR score, subgroups of LNR were made on quartiles. For each subgroup 5 year survival rate was calculated and comparison between groups was carried out.  RESULTS: There were 104 patients on N0, 38 on N1 and 58 on N2 stage. Survival rate at 5 years was 61.30% for the NO subgroup, 18.70% for the N1 subgroup, and 12.31% for the N2 subgroup (Fig. 1). The most significant p value, was reported between N0 and N1 as well as between N0 and N2 subgroup (p=0.001). Nodes positive were 44 a LNR ranging from 1% to 25% (1% < LNR < 25%); 24 patients from 26% to 50% (26% < LNR < 50%). In 6 patients LNR was ranging from 51% to 75% (51% < LNR 75%) and in 8 patients from 76% to 100% (76% < LNR 100%); overall survival rate in different quartiles was respectively 27.12%, 9.38%, 16.67% and 1.56%.  CONCLUSION: LNR is a reliable prognostic index in post surgical colorectal cancer staging.

Item Type: Article
Uncontrolled Keywords: aged,colorectal neoplasms,female,humans,lymph nodes,lymphatic metastasis,male,neoplasm staging,retrospective studies
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Pure Connector
Date Deposited: 17 Mar 2016 11:01
Last Modified: 22 Apr 2020 01:10
URI: https://ueaeprints.uea.ac.uk/id/eprint/57514
DOI:

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