A SPION-eicosane protective coating for water soluble capsules:Evidence for on-demand drug release triggered by magnetic hyperthermia

Che Rose, Laili, Bear, Joseph C., McNaughter, Paul, Southern, Paul, Piggott, R. Ben, Parkin, Ivan P., Qi, Sheng and Mayes, Andrew (2016) A SPION-eicosane protective coating for water soluble capsules:Evidence for on-demand drug release triggered by magnetic hyperthermia. Scientific Reports, 6. ISSN 2045-2322

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Abstract

An orally-administered system for targeted, on-demand drug delivery to the gastrointestinal (GI) tract is highly desirable due to the high instances of diseases of that organ system and harsh mechanical and physical conditions any such system has to endure. To that end, we present an iron oxide nanoparticle/wax composite capsule coating using magnetic hyperthermia as a release trigger. The coating is synthesised using a simple dip-coating process from pharmaceutically approved materials using a gelatin drug capsule as a template. We show that the coating is impervious to chemical conditions within the GI tract and is completely melted within two minutes when exposed to an RF magnetic field under biologically-relevant conditions. The overall simplicity of action, durability and non-toxic and inexpensive nature of our system demonstrated herein are key for successful drug delivery systems.

Item Type: Article
Additional Information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Faculty \ School: Faculty of Science > School of Chemistry
Faculty of Science > School of Pharmacy
Depositing User: Pure Connector
Date Deposited: 24 Feb 2016 08:09
Last Modified: 24 Nov 2020 00:54
URI: https://ueaeprints.uea.ac.uk/id/eprint/57230
DOI: 10.1038/srep20271

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