Dietary flavonoid intake and incidence of erectile dysfunction

Cassidy, Aedin, Franz, Mary and Rimm, Eric B. (2016) Dietary flavonoid intake and incidence of erectile dysfunction. American Journal of Clinical Nutrition, 103 (2). pp. 534-541. ISSN 0002-9165

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Background: The predominant etiology for erectile dysfunction (ED) is vascular, however limited data are available on the role of diet. A higher intake of several flavonoids reduces diabetes and cardiovascular disease (CVD) risk but no studies have examined associations between flavonoids and erectile function.   Objective: To examine the relationship between habitual flavonoid sub-class intakes and incidence of ED.   Methods: We conducted a prospective study among 25,096 men from the Health Professionals Follow-up Study. Total flavonoid and subclass intakes were calculated from food frequency questionnaires collected every 4 years. Participants rated their erectile function in 2000 (with historical reporting from 1986) and again in 2004 and 2008.   Results: During 10 years of follow-up, 35.6% reported incident ED. After multivariate adjustment, including classic CVD risk factors, several sub-classes were associated with reduced ED incidence; specifically flavones (RR 0.91:95%CI=0.85,0.97; p-trend=0.006), flavanones (RR 0.89;95%CI=0.83,0.95; p-trend=0.0009), and anthocyanins (RR 0.91;95%CI=0.85,0.98; p-trend=0.002) comparing extreme intakes. The results remained significant after additional adjustment for a composite dietary intake score. In analyses stratified by age, a higher intake of flavanones, anthocyanins and flavones was significantlyassociated with a reduction in risk of erectile dysfunction only in men <70 years old and not older men (11-16% reduction in risk (p - interaction 0.002, 0.03, 0.007 for flavones, flavanones and anthocyanins respectively). In food-based analysis, higher total fruit intake, major sources of anthocyanins and flavanones, was associated with 14% reduction in risk of ED (RR 0.86;95%CI=0.79,0.92; p=0.002).The American Journal of Clinical Nutrition AJCN/2015/122010 Version 3.    Conclusions : These data suggest that a higher habitual intake of specific 24 flavonoid-rich foods are associated with reduced ED incidence. Intervention trials are needed to further examine the impact of increasing intakes of commonly consumed flavonoid-rich foods on men’s health.

Item Type: Article
Additional Information: This is an open access article distributed under the CC-BY license (
Uncontrolled Keywords: anthocyanins ,erectile dysfunction ,flavanones ,flavones ,flavonoids,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Depositing User: Pure Connector
Date Deposited: 17 Feb 2016 17:00
Last Modified: 28 Oct 2022 08:27
DOI: 10.3945/ajcn.115.122010


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