Atlas Toolkit: Fast registration of 3D morphological datasets in the absence of landmarks

Grocott, Timothy ORCID:, Thomas, Paul and Munsterberg, Andrea ORCID: (2016) Atlas Toolkit: Fast registration of 3D morphological datasets in the absence of landmarks. Scientific Reports, 6. ISSN 2045-2322

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Image registration is a gateway technology for Developmental Systems Biology, enabling computational analysis of related datasets within a shared coordinate system. Many registration tools rely on landmarks to ensure that datasets are correctly aligned; yet suitable landmarks are not present in many datasets. Atlas Toolkit is a Fiji/ImageJ plugin collection offering elastic group-wise registration of 3D morphological datasets, guided by segmentation of the interesting morphology. We demonstrate the method by combinatorial mapping of cell signalling events in the developing eyes of chick embryos, and use the integrated datasets to predictively enumerate Gene Regulatory Network states.

Item Type: Article
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Faculty \ School: Faculty of Science > School of Biological Sciences
Faculty of Science
UEA Research Groups: Faculty of Science > Research Groups > Cells and Tissues
Depositing User: Pure Connector
Date Deposited: 17 Feb 2016 16:00
Last Modified: 19 Apr 2023 23:48
DOI: 10.1038/srep20732


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