In vitro determination of hemoglobin A1c for diabetes diagnosis and management: technology update

English, Emma, John, W Garry and Milosevich, Elise T (2014) In vitro determination of hemoglobin A1c for diabetes diagnosis and management: technology update. Pathology and Laboratory Medicine International, 6. pp. 21-31. ISSN 1179-2698

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Abstract

It is fascinating to consider the analytical improvements that have occurred since glycated hemoglobin was first used in routine clinical laboratories for diabetes monitoring around 1977; at that time methods displayed poor precision, there were no calibrators or material with assayed values for quality control purposes. This review outlines the major improvements in hemoglobin A1c (HbA1c) measurement that have occurred since its introduction, and reflects on the increased importance of this hemoglobin fraction in the monitoring of glycemic control. The use of HbA1c as a diagnostic tool is discussed in addition to its use in monitoring the patient with diabetes; the biochemistry of HbA1c formation is described, and how these changes to the hemoglobin molecule have been used to develop methods to measure this fraction. Standardization of HbA1c is described in detail; the development of the IFCC Reference Measurement Procedure for HbA1c has enabled global standardization to be achieved which has allowed global targets to be set for glycemic control and diagnosis. The importance of factors that may interfere in the measurement of HbA1c are highlighted.

Item Type: Article
Additional Information: This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.
Uncontrolled Keywords: glycated hemoglobin, hba1c,ifcc
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:
Depositing User: Pure Connector
Date Deposited: 27 Jan 2016 16:00
Last Modified: 12 Aug 2020 23:41
URI: https://ueaeprints.uea.ac.uk/id/eprint/56809
DOI: 10.2147/PLMI.S48403

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