The Mini-Addenbrooke's Cognitive Examination: A new assessment tool for dementia

Hsieh, H., McGrory, S., Leslie, F., Dawson, K., Ahmed, S., Butler, C. R., Rowe, J. B., Mioshi, E. and Hodges, J. R. (2015) The Mini-Addenbrooke's Cognitive Examination: A new assessment tool for dementia. Dementia and Geriatric Cognitive Disorders, 39 (1-2). ISSN 1420-8008

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BACKGROUND/AIMS: We developed and validated the Mini-Addenbrooke's Cognitive Examination (M-ACE) in dementia patients. Comparisons were also made with the Mini Mental State Examination (MMSE). METHOD: The M-ACE was developed using Mokken scaling analysis in 117 dementia patients [behavioural variant frontotemporal dementia (bvFTD), n = 25; primary progressive aphasia (PPA), n = 49; Alzheimer's disease (AD), n = 34; corticobasal syndrome (CBS), n = 9] and validated in an independent sample of 164 dementia patients (bvFTD, n = 23; PPA, n = 82; AD, n = 38; CBS, n = 21) and 78 controls, who also completed the MMSE. RESULTS: The M-ACE consists of 5 items with a maximum score of 30. Two cut-offs were identified: (1) ≤25/30 has both high sensitivity and specificity, and (2) ≤21/30 is almost certainly a score to have come from a dementia patient regardless of the clinical setting. The M-ACE is more sensitive than the MMSE and is less likely to have ceiling effects. CONCLUSION: The M-ACE is a brief and sensitive cognitive screening tool for dementia. Two cut-offs (25 or 21) are recommended.

Item Type: Article
Uncontrolled Keywords: cognitive screening test,frontotemporal dementia,alzheimer’s disease ,corticobasal degeneration
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Dementia & Complexity in Later Life
Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
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Depositing User: Pure Connector
Date Deposited: 19 Jan 2016 10:00
Last Modified: 19 Oct 2023 01:37
DOI: 10.1159/000366040


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