Histone deacetylases as new therapy targets for platinum-resistant epithelial ovarian cancer

Pchejetski, Dmitri, Alfraidi, Albandri, Sacco, Keith, Alshaker, Heba, Muhammad, Aun and Monzon, Leonardo (2016) Histone deacetylases as new therapy targets for platinum-resistant epithelial ovarian cancer. Journal of Cancer Research and Clinical Oncology, 142 (8). 1659–1671. ISSN 1432-1335

[img]
Preview
PDF (Published manuscript) - Published Version
Available under License Creative Commons Attribution.

Download (928kB) | Preview

Abstract

Introduction: In developed countries, ovarian cancer is the fourth most common cancer in women. Due to the nonspecific symptomatology associated with the disease many patients with ovarian cancer are diagnosed late, which leads to significantly poorer prognosis. Apart from surgery and radiotherapy, a substantial number of ovarian cancer patients will undergo chemotherapy and platinum based agents are the mainstream first-line therapy for this disease. Despite the initial efficacy of these therapies, many women relapse; therefore, strategies for second-line therapies are required. Regulation of DNA transcription is crucial for tumour progression, metastasis and chemoresistance which offers potential for novel drug targets. Methods: We have reviewed the existing literature on the role of histone deacetylases, nuclear enzymes regulating gene transcription. Results and conclusion: Analysis of available data suggests that a signifant proportion of drug resistance stems from abberant gene expression, therefore HDAC inhibitors are amongst the most promising therapeutic targets for cancer treatment. Together with genetic testing, they may have a potential to serve as base for patient-adapted therapies.

Item Type: Article
Additional Information: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Uncontrolled Keywords: hdacs,platinum resistance,ovarian cancer,platinum,chemotherapy,molecular targeting
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:
Depositing User: Pure Connector
Date Deposited: 07 Jan 2016 10:04
Last Modified: 19 Aug 2020 23:43
URI: https://ueaeprints.uea.ac.uk/id/eprint/56110
DOI: 10.1007/s00432-015-2064-5

Actions (login required)

View Item View Item