Tools
Tools
Hornberger, Michael 
ORCID: https://orcid.org/0000-0002-2214-3788, Piguet, Olivier, Kipps, Christopher and Hodges, John R.
(2008)
Executive function in progressive and nonprogressive behavioral variant frontotemporal dementia.
Neurology, 71 (19).
pp. 1481-1488.
ISSN 0028-3878
Abstract
Background: Recent studies suggest that behavioral variant frontotemporal dementia (bv-FTD) patients differ in their prognosis with fast-progressing and very slowĝ€"progressing cases. We investigated executive and behavioral profiles of progressive and nonprogressive bv-FTD patients to establish diagnostic markers discriminating the two groups. Methods: A range of neuropsychological and behavioral tests were used. Mean overlap-based statistical analyses and logistic regression analyses were performed to distinguish progressive from nonprogressive bv-FTD cases. Results: Although progressors and nonprogressors showed similar behavioral profiles, they were distinguishable by their performance on executive tasks. The nonprogressorsg performance on all tests was with the normal range, whereas the progressors were consistently impaired on four tests: Digit Span Backward, Hayling Test of inhibitory control, Letter Fluency, and Trails B. Logistic regression showed that 86% of patients could be classified on the basis of Digit Span and Hayling subscores. Conclusions: Contrary to some prior reports, behavioral variant frontotemporal dementia (bv-FTD) patients who progress over time are typically impaired on executive tasks at first presentation, although an important minority of true FTD patients perform normally. Previous inconsistencies are explicable by the mixture of patients with progressing FTD and phenocopy cases.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Mental Health Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health |
| Related URLs: | |
| Depositing User: | Pure Connector |
| Date Deposited: | 05 Jan 2016 11:00 |
| Last Modified: | 19 Oct 2023 01:36 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/55999 |
| DOI: | 10.1212/01.wnl.0000334299.72023.c8 |
Actions (login required)
 |
View Item |