Can progressive and non-progressive behavioural variant frontotemporal dementia be distinguished at presentation?

Hornberger, M., Shelley, B. P., Kipps, C. M., Piguet, O. and Hodges, J. R. (2009) Can progressive and non-progressive behavioural variant frontotemporal dementia be distinguished at presentation? Journal of Neurology, Neurosurgery and Psychiatry, 80 (6). pp. 591-593. ISSN 0022-3050

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Abstract

Background: Recent findings suggest that patients with behavioural variant frontotemporal dementia (bv-FTD) differ in their disease progression (progressive vs nonprogressive patients). The current study investigates whether the two groups can be discriminated by their clinical features at first presentation.   Methods: Archival clinical data of the Early Onset Dementia Clinic, Cambridge, UK, were analysed for 71 patients with bv-FTD: 45 progressive and 26 nonprogressive cases with more than 3 years of follow-up.   Results: The subgroups were largely indistinguishable on the basis of the presenting clinical features but could be distinguished on general cognitive (Addenbrooke's Cognitive Examination-revised) and selected supportive diagnostic features (distractibility, stereotypic speech, impaired activities of daily living (ADLs) and current depression).   Conclusions: Progressive and non-progressive patients are difficult to differentiate on the basis of current clinical diagnostic criteria for FTD but a combination of general cognitive, executive dysfunction and impaired ADL measures appear to be the most promising discriminators.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Pure Connector
Date Deposited: 05 Jan 2016 11:00
Last Modified: 22 Apr 2020 00:51
URI: https://ueaeprints.uea.ac.uk/id/eprint/55997
DOI: 10.1136/jnnp.2008.163873

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