Are judgments of semantic relatedness systematically impaired in Alzheimer's disease?

Hornberger, M. ORCID:, Bell, B., Graham, K. S. and Rogers, T. T. (2009) Are judgments of semantic relatedness systematically impaired in Alzheimer's disease? Neuropsychologia, 47 (14). pp. 3084-3094. ISSN 0028-3932

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We employed a triadic comparison task in patients with Alzheimer's disease (AD) and healthy controls to contrast (a) multidimensional scaling (MDS) and accuracy-based assessments of semantic memory, and (b) degraded-store versus degraded-access accounts of semantic impairment in Alzheimer's disease (AD). Similar to other studies using triadic comparison tasks, participants were asked to indicate which two out of three words (animal names) were most similar in meaning. Novel to this investigation, we contrasted performance on two semantic dimensions of strong and equal saliency to controls, but varying in their specificity (land/water versus bird/non-bird). Degraded-store accounts predict that the more specific bird/non-bird dimension should be more consistently impaired in AD, whereas degraded-access accounts predict that both dimensions, because they are equally salient, should be equivalently impaired in the disorder. The MDS results suggested that both patient and control group responses were not discriminable from random responding, consistent with previous studies. By contrast an accuracy-based analysis on the same data showed that controls showed good knowledge of both salient dimensions, and were evenly split in their individual preference for one dimension over another. In contrast, patients showed higher accuracy and sensitivity to the broader land/water dimension than to the more specific bird/non-bird dimension, consistent with a storage-based account of the semantic impairment in AD. Our results further suggest that MDS methods can fail to reveal important and systematic behaviour in semantic tasks, in both patient and control groups.

Item Type: Article
Uncontrolled Keywords: alzheimer's disease,multidimensional scaling,semantic memory,semantic specificity,triadic comparison task
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Mental Health
Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
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Depositing User: Pure Connector
Date Deposited: 05 Jan 2016 10:02
Last Modified: 19 Oct 2023 01:36
DOI: 10.1016/j.neuropsychologia.2009.07.006

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