Orbitofrontal dysfunction discriminates behavioral variant frontotemporal dementia from Alzheimer's disease

Hornberger, M ORCID: https://orcid.org/0000-0002-2214-3788, Savage, S, Hsieh, S, Mioshi, E, Piguet, O and Hodges, J R (2010) Orbitofrontal dysfunction discriminates behavioral variant frontotemporal dementia from Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 30 (6). pp. 547-552. ISSN 1420-8008

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BACKGROUND: Behavioral variant frontotemporal dementia (bvFTD) patients show prefrontal cortex dysfunction and atrophy.   METHODS: We investigated whether executive function in conjunction with prefrontal cortex atrophy discriminates bvFTD and Alzheimer's disease (AD) patients efficiently at presentation.   RESULTS: AD and bvFTD patients were distinguishable by 89.5% on their performance of 3 executive tasks: the Hayling Test of Inhibitory Control, Digit Span Backward and Letter Fluency. Similarly, scan ratings showed that orbitofrontal cortex (OFC) and dorsolateral prefrontal cortex regions distinguish both patient groups. More importantly, employing the Hayling error score in conjunction with the OFC atrophy rating showed that 92% of patients can be correctly classified into bvFTD and AD.   CONCLUSION: A combination of OFC and disinhibition measures appears to be a powerful diagnostic tool in differentiating bvFTD from AD patients in this preliminary study.

Item Type: Article
Additional Information: Copyright © 2011 S. Karger AG, Basel.
Uncontrolled Keywords: aged,alzheimer disease,behavior,brain,diagnosis, differential,executive function,female,frontotemporal dementia,humans,image processing, computer-assisted,magnetic resonance imaging,male,middle aged,neuropsychological tests
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Medicine and Health Sciences > School of Health Sciences
Depositing User: Pure Connector
Date Deposited: 05 Jan 2016 10:00
Last Modified: 28 Oct 2022 08:28
URI: https://ueaeprints.uea.ac.uk/id/eprint/55987
DOI: 10.1159/000321670

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