Differential impairment of source memory in progressive versus non-progressive behavioral variant frontotemporal dementia

Irish, Muireann, Graham, Andrew, Graham, Kim S., Hodges, John R. and Hornberger, Michael (2012) Differential impairment of source memory in progressive versus non-progressive behavioral variant frontotemporal dementia. Archives of Clinical Neuropsychology, 27 (3). pp. 338-347. ISSN 1873-5843

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Abstract

Episodic memory has recently been shown to be impaired in the behavioral variant of frontotemporal dementia (bvFTD) when so-called non-progressive cases are excluded. Such non-progressive cases present with the behavioral features of bvFTD, but show no evidence of cognitive decline over time. To date, evidence regarding episodic memory performance in bvFTD subgroups on more stringent tasks is lacking. We investigated temporal and spatial source memory in progressive (n = 7) versus non-progressive (n = 12) bvFTD. BvFTD cases were retrospectively classified based on general cognitive decline on the Addenbrooke's Cognitive Examination Revised, and the presence of atrophy on structural neuroimaging, over 3 years following diagnosis. Progressors showed impaired temporal and spatial source retrieval. Non-progressors displayed temporal source deficits only. These differential source memory profiles point to the variability of episodic memory performance in bvFTD, and underscore the importance of differential diagnosis of bvFTD subgroups using longitudinal and neuroimaging data.

Item Type: Article
Uncontrolled Keywords: differential diagnosis,episodic memory,frontotemporal dementia,source memory
Faculty \ School: Faculty of Social Sciences > School of Psychology
Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Pure Connector
Date Deposited: 04 Jan 2016 17:01
Last Modified: 28 Oct 2019 14:03
URI: https://ueaeprints.uea.ac.uk/id/eprint/55977
DOI: 10.1093/arclin/acs033

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