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Tan, Rachel H., Wong, Stephanie, Hodges, John R., Halliday, Glenda M. and Hornberger, Michael 
ORCID: https://orcid.org/0000-0002-2214-3788
(2013)
Retrosplenial cortex (BA 29) volumes in behavioral variant frontotemporal dementia and alzheimer's disease.
Dementia and Geriatric Cognitive Disorders, 35 (3-4).
pp. 177-182.
ISSN 1420-8008
Abstract
Background: The retrosplenial cortex (RSC) is a crucial transit region between the hippocampus and cingulate cortex and has been implicated in spatial navigation and memory. Importantly, RSC atrophy is a predilection site of Alzheimer's (AD) pathology, but there have been no studies assessing structural changes in the RSC in behavioral variant frontotemporal dementia (bvFTD). Methods: A manual tracing method was used to calculate regional RSC volume in MRI scans from patients with bvFTD (n = 15) and AD (n = 15), as well as age- and sex-matched controls (n = 15). Results: RSC volumes were significantly reduced in the AD (p < 0.001), but not the bvFTD cohort (p > 0.1) compared to age-matched controls. RSC volumes discriminated bvFTD from AD in over 90% of the cases. Conclusion: These findings provide further evidence that RSC atrophy is specific to AD, which might explain the commonly observed spatial disorientation in this patient group.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | alzheimer's disease,ba29,behavioral variant frontotemporal dementia,retrosplenial cortex,volumetric tracing |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Mental Health Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health |
| Related URLs: | |
| Depositing User: | Pure Connector |
| Date Deposited: | 04 Jan 2016 17:00 |
| Last Modified: | 19 Oct 2023 01:35 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/55968 |
| DOI: | 10.1159/000346392 |
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