Retrosplenial cortex (BA 29) volumes in behavioral variant frontotemporal dementia and alzheimer's disease

Tan, Rachel H., Wong, Stephanie, Hodges, John R., Halliday, Glenda M. and Hornberger, Michael ORCID: https://orcid.org/0000-0002-2214-3788 (2013) Retrosplenial cortex (BA 29) volumes in behavioral variant frontotemporal dementia and alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 35 (3-4). pp. 177-182. ISSN 1420-8008

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Abstract

Background: The retrosplenial cortex (RSC) is a crucial transit region between the hippocampus and cingulate cortex and has been implicated in spatial navigation and memory. Importantly, RSC atrophy is a predilection site of Alzheimer's (AD) pathology, but there have been no studies assessing structural changes in the RSC in behavioral variant frontotemporal dementia (bvFTD).   Methods: A manual tracing method was used to calculate regional RSC volume in MRI scans from patients with bvFTD (n = 15) and AD (n = 15), as well as age- and sex-matched controls (n = 15).   Results: RSC volumes were significantly reduced in the AD (p < 0.001), but not the bvFTD cohort (p > 0.1) compared to age-matched controls. RSC volumes discriminated bvFTD from AD in over 90% of the cases.   Conclusion: These findings provide further evidence that RSC atrophy is specific to AD, which might explain the commonly observed spatial disorientation in this patient group.

Item Type: Article
Uncontrolled Keywords: alzheimer's disease,ba29,behavioral variant frontotemporal dementia,retrosplenial cortex,volumetric tracing
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Pure Connector
Date Deposited: 04 Jan 2016 17:00
Last Modified: 24 Sep 2022 00:20
URI: https://ueaeprints.uea.ac.uk/id/eprint/55968
DOI: 10.1159/000346392

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