Neural correlates of activities of daily living in frontotemporal dementia

Mioshi, E., Hodges, J. R. and Hornberger, M. ORCID: (2013) Neural correlates of activities of daily living in frontotemporal dementia. Journal of Geriatric Psychiatry and Neurology, 26 (1). pp. 51-57. ISSN 0891-9887

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Background: Little research to date has investigated neural correlates of functional disability in frontotemporal dementia (FTD).   Methods: Activities of daily living (ADL) were covaried against gray matter atrophy regions via Voxel-based morphometry in FTD (n = 52) and contrasted against a dementia control Alzheimer disease (AD) group (n = 20) and healthy age-matched controls (n = 18).   Results: Both patient groups had similar ADL scores. However, FTD and AD differed on the gray matter atrophy areas associated with ADL scores. The FTD showed involvement of prefrontal and thalamus regions while AD showed widespread temporal, parietal, frontal, and caudate atrophy correlating with ADL dysfunction. Importantly, only the left superior frontal gyrus was implicated in ADL dysfunction for both FTD and AD.   Conclusions: Differences in underlying neural correlates of ADL impairment have important clinical implications as these differences should be taken into account when interventions are planned. Dementia subtypes might require specifically tailored interventions for functional disability.

Item Type: Article
Uncontrolled Keywords: activities of daily living,alzheimer disease,disability assessment for dementia,frontotemporal dementia,functional disability,voxel-based morphometry
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Pure Connector
Date Deposited: 04 Jan 2016 16:00
Last Modified: 22 Oct 2022 00:35
DOI: 10.1177/0891988713477474

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