Medial temporal lobe contributions to intra-item associative recognition memory in the aging brain

Dalton, Marshall Axel, Tu, Sicong, Hornberger, Michael, Hodges, John Russel and Piguet, Olivier (2014) Medial temporal lobe contributions to intra-item associative recognition memory in the aging brain. Frontiers in Behavioral Neuroscience, 7. ISSN 1662-5153

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Abstract

Aging is associated with a decline in episodic memory function. This is accompanied by degradation of and functional changes in the medial temporal lobe (MTL) which subserves mnemonic processing. To date no study has investigated age-related functional change in MTL substructures during specific episodic memory processes such as intra-item associative memory. The aim of this study was to characterize age-related change in the neural correlates of intra-item associative memory processing. Sixteen young and 10 older subjects participated in a compound word intra-item associative memory task comprising a measure of associative recognition memory and a measure of recognition memory. There was no difference in performance between groups on the associative memory measure but each group recruited different MTL regions while performing the task.The young group recruited the left anterior hippocampus and posterior parahippocampal gyrus whereas the older participants recruited the hippocampus bilaterally. In contrast, recognition memory was significantlyworse in the older subjects.The left anterior hippocampuswas recruited in the young group during successful recognition memory whereas the older group recruited a more posterior region of the left hippocampus and showed a more bilateral activation of frontal brain regions than was observed in the young group. Our results suggest a reorganization of the neural correlates of intra-item associative memory in the aging brain.

Item Type: Article
Additional Information: © 2014 Dalton, Tu, Hornberger, Hodges and Piguet. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Uncontrolled Keywords: aging,associative memory,hippocampus,medial temporal lobe,perirhinal cortex
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Pure Connector
Date Deposited: 04 Jan 2016 14:01
Last Modified: 27 Oct 2020 00:43
URI: https://ueaeprints.uea.ac.uk/id/eprint/55946
DOI: 10.3389/fnbeh.2013.00222

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