Accelerated forgetting of contextual details due to focal medio-dorsal thalamic lesion

Tu, Sicong, Miller, Laurie, Piguet, Olivier and Hornberger, Michael (2014) Accelerated forgetting of contextual details due to focal medio-dorsal thalamic lesion. Frontiers in Behavioral Neuroscience, 8. ISSN 1662-5153

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Effects of thalamic nuclei damage and related white matter tracts on memory performance are still debated. This is particularly evident for the medio-dorsal thalamus which has been less clear in predicting amnesia than anterior thalamus changes. The current study addresses this issue by assessing 7 thalamic stroke patients with consistent unilateral lesions focal to the left medio-dorsal nuclei for immediate and delayed memory performance on standard visual and verbal tests of anterograde memory, and over the long-term (>24 h) on an object-location associative memory task. Thalamic patients showed selective impairment to delayed recall, but intact recognition memory. Patients also showed accelerated forgetting of contextual details after a 24 h delay, compared to controls. Importantly, the mammillothalamic tract was intact in all patients, which suggests a role for the medio-dorsal nuclei in recall and early consolidation memory processes.

Item Type: Article
Uncontrolled Keywords: thalamus,anterograde memory,stroke,mammillothalamic tract,mri
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 22 Dec 2015 16:02
Last Modified: 30 Sep 2021 07:08
DOI: 10.3389/fnbeh.2014.00320

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